Correlation of ferritin, D-dimer, and CRP with disease severity and outcome in COVID-19 patients

Ia Murvanidze; Ilia Nakashidze; Teona Gogitidze; Ermira Jahja; Aleena Parveen Shaikh; Nino Tebidze; Nameera Parveen Shaikh; Besik Kakabadze; Maia Resulidze; Rajneesh Khurana; Eteri Saralidze; Otar Tsetskhladze; Davit Baratashvili; Nino Kedelidze; Tamar Peshkova; Irina Nakashidze

doi:10.62063/ecb-59

Authors

Ia Murvanidze Batumi Shota Rustaveli State University https://orcid.org/0000-0002-2351-9177
Ilia Nakashidze Batumi Shota Rustaveli State University https://orcid.org/0009-0007-3365-7788
Teona Gogitidze BAU International University https://orcid.org/0000-0003-3451-5777
Ermira Jahja Western Balkans University https://orcid.org/0000-0003-2941-5173
Aleena Parveen Shaikh Batumi Shota Rustaveli State University https://orcid.org/0000-0002-1473-4334
Nino Tebidze BAU International University https://orcid.org/0000-0002-0769-7010
Nameera Parveen Shaikh BAU International University https://orcid.org/0000-0002-7393-0263
Besik Kakabadze Batumi Shota Rustaveli State University https://orcid.org/0009-0002-4557-4545
Maia Resulidze Batumi Shota Rustaveli State University https://orcid.org/0009-0003-8821-5566
Rajneesh Khurana Montefiore Medical Center https://orcid.org/0000-0002-8856-4120
Eteri Saralidze Batumi Shota Rustaveli State University https://orcid.org/0000-0001-6841-1525
Otar Tsetskhladze Batumi Shota Rustaveli State University https://orcid.org/0009-0006-7177-6297
Davit Baratashvili Batumi Shota Rustaveli State University
Nino Kedelidze Batumi Shota Rustaveli State University https://orcid.org/0000-0002-1414-9653
Tamar Peshkova Batumi Shota Rustaveli State University https://orcid.org/0009-0009-4579-5170
Irina Nakashidze Batumi Shota Rustaveli State University https://orcid.org/0000-0001-8934-6312

DOI:

https://doi.org/10.62063/ecb-59

Keywords:

Ferritin, COVID-19, Recovered patients, Lethal outcome

Abstract

Higher levels of ferritin were associated with severe forms of COVID-19 disease. Given the above, our goal was to investigate the associations between ferritin levels within COVID-19-infected individuals from the Adjara population (Georgia). A nasopharyngeal swab was collected from 318 individuals, and SARS-CoV-2 infection was detected using the polymerase chain reaction (PCR) method. Ferritin levels were also investigated in the blood serum of the same individuals. Thus, the study of ferritin in COVID-19 patients (in the Adjara population revealed significantly higher ferritin levels in COVID-19 patients. Higher levels of ferritin were detected in the male subjects than in the female population (p=0.0001). COVID-19 patients with lethal outcomes had nearly ~3 times higher levels of ferritin than the reference value, while those who successfully recovered had ~1.9 times above the reference value. It should be noted that the individuals with lethal outcomes were between 81 and 90 years old. An increased level of D-dimer compared to the reference level was also detected in the male population and was nearly ~4.1 times higher in those with lethal outcomes. D-dimer was also significantly increased in patients at the age 71-80 years, while their CRP levels were approximately ~5.8 times above the reference level; Moreover, CRP level was ~24.4 times increased in the case of women with lethal outcomes; In particular, according to the comparing age groups, a high level of CRP was observed in 61-70 years patients. Our study revealed that the diseased population exhibited significantly higher ferritin levels. The ferritin levels in patients with lethal outcomes were considerably higher than those in patients who successfully recovered. Thus, the findings reveal a noteworthy elevation in D-dimer levels, particularly in men and deceased patients, with a notable elevation in the 71-80 age group. Additionally, CRP levels were markedly higher, especially among deceased women and individuals aged 61-70.

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