Investigation of antiproliferative and  antimicrobial activities of carbon nanofiber  based aerogels loaded with rutin and krill oil

Berkan Aktas; Merve Gurboga; Sinem Angin; Pervin Rayaman; Elif Caliskan Salihi; Ozlem Bingol Ozakpinar

doi:10.62063/ecb-29

Authors

Berkan Aktas Marmara University, Faculty of Pharmacy, Basic Pharmaceutical Sciences, Department of Biochemistry, Istanbul, Türkiye https://orcid.org/0009-0001-0449-5907
Merve Gurboga Marmara University, Faculty of Pharmacy, Basic Pharmaceutical Sciences, Department of Biochemistry, Istanbul, Türkiye https://orcid.org/0000-0003-4614-7094
Sinem Angin Marmara University, Faculty of Pharmacy, Basic Pharmaceutical Sciences, Department of Biochemistry, Istanbul, Türkiye https://orcid.org/0009-0006-1996-1444
Pervin Rayaman Marmara University, Faculty of Pharmacy, Basic Pharmaceutical Sciences, Department of Pharmaceutical Microbiology, Istanbul, Türkiye https://orcid.org/0000-0002-0487-8692
Elif Caliskan Salihi Marmara University, Faculty of Pharmacy, Basic Pharmaceutical Sciences, Department of Basic Pharmacy Sciences, Istanbul, Türkiye https://orcid.org/0000-0001-7852-3782
Ozlem Bingol Ozakpinar Marmara University, Faculty of Pharmacy, Basic Pharmaceutical Sciences, Department of Biochemistry, Istanbul, Türkiye https://orcid.org/0000-0003-0287-5639

DOI:

https://doi.org/10.62063/ecb-29

Keywords:

Aerogel, antimicrobial effects, cancer, carbon nanofiber, krill oil

Abstract

Cancer, the second-leading cause of death worldwide after cardiovascular diseases, is a deadly disease caused by numerous mutations that affect cell growth and differentiation. While there is no definitive cure for cancer yet, new target molecules are being identified with the help of developing technology, and appropriate treatment protocols are being developed. Since both normal and malignant cells are exposed to cytotoxic effects in traditional treatment methods, the development of less-side-effect and targeted treatment methods has become important. With the development of nanotechnology, the development of various nanodrug delivery systems (DDSs) has been targeted. In our study, we investigated the antiproliferative and antimicrobial activities of rutin-modified carbon nanofiber (ACNFr)-based aerogels loaded with krill oil (KO) (ACNFr-KO). Our results showed that ACNFr-KO aerogels were observed to have a significant anti-proliferative effect on the human breast cancer cell line MCF-7. In addition to this, ACNFr-KO aerogels were found to have antimicrobial activity against the gram-positive bacterium E. faecalis ATCC 29212. The results of our study suggest that rutin-modified CNF-based aerogels loaded with KO, which act as a DDS, have the potential to enhance targeted drug delivery and improve therapeutic outcomes in biomedical applications.

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